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hydrolase$36458$ - translation to English
MAMMALIAN PROTEIN FOUND IN HOMO SAPIENS
Kynurenine hydrolase; KYNU (gene); EC 3.7.1.3; L-kynurenine hydrolase
hydrolase
n. Hydrolase (Enzym)
Definition
lysin
['l??s?n]
¦ noun Biology an antibody or other substance able to cause lysis of cells (especially bacteria).
Wikipedia
Kynureninase
Kynureninase or L-Kynurenine hydrolase (KYNU) (EC 3.7.1.3) is a PLP dependent enzyme that catalyses the cleavage of kynurenine (Kyn) into anthranilic acid (Ant). It can also act on 3-hydroxykynurenine (to produce 3-hydroxyanthranilate) and some other (3-arylcarbonyl)-alanines. Humans express one kynureninase enzyme that is encoded by the KYNU gene located on chromosome 2.
KYNU is part of the pathway for the catabolism of Trp and the biosynthesis of NAD cofactors from tryptophan (Trp).
Kynureninase catalyzes the following reaction:
- L-kynurenine + H2O ↔ anthranilate + L-alanine
